One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Ocular testing for plaquenil Chloroquine diphosphate intercalator Plaquenil and eyes Chloroquine over the counter Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1%. Multifocal ERG testing can detect abnormal function in chloroquine retinopathy even when the full-field ERG appears normal and visible macular alterations are subtle. The mfERG of patients with retinopathy can be altered in many ways including generalized depression of the mfERG, loss of the central peak waveform, as well as a pericentral loss. Worsening of psoriasis and porphyria Use of PLAQUENIL in patients with psoriasis may precipitate a severe attack of psoriasis. When used in patients with porphyria the condition may be exacerbated. When used in patients with porphyria the condition may be exacerbated. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil ful fielderg severe Plaquenil oral Reviews and User Ratings Effectiveness, Ease., Multifocal ERG in Practice - Chloroquine resistant malaria drugsHydroxychloroquine 200 mg tabletPlaquenil and veinsHydroxychloroquine usos Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Multimodal Imaging in Plaquenil Toxicity. Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert. Hydroxychloroquine-related retinal toxicity Rheumatology.. Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. Tell your doctor immediately if any of these rare but very serious side effects occur severe stomach/abdominal pain, severe nausea/vomiting, easy bleeding/bruising, signs of infection e.g. fever, persistent sore throat, seizures, shortness of breath, swelling ankles/feet, extreme tiredness, dark urine, yellowing eyes/skin. A total of 226 drugs are known to interact with Plaquenil, including 8 major drug interactions. For a full list that can be easily searched, visit You should avoid taking antacids or Kaopectate within 4 hours of taking Plaquenil. Some antacids may make it harder for your body to absorb the medication.