Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil drug nutrient interactions Plaquenil and chronic fatigue Hydroxychloroquine risk Plaquenil eye toxicity symptoms Hydroxychloroquine is an antimalarial drug. It treats malaria by killing the parasites that cause the disease. It isn’t fully understood how this drug works to treat lupus erythematosus or. Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine in rheumatoid arthritis mechanism of action Hydroxychloroquine - Alberta Rheumatology, Hydroxychloroquine decreases Th17-related cytokines in. Methylene blue falciparum chloroquine sensitizeMarine chloroquine phosphateOk to stop taking hydroxychloroquine Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. Treatments for Rheumatoid Arthritis. Mechanism of action of hydroxychloroquine as an antirheumatic.. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents. Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. The presence of retinal or visual field changes attributable to any 4-aminoquinoline compound like chloroquine, and in patients with known hypersensitivity to 4-aminoquinoline compounds.