Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine for lupus What is in plaquenil Chloroquine quinine in a fish dt Plaquenil for ankylosing spondylitis Apr 10, 2019 Common Plaquenil side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Sep 13, 2019 Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. I started to take plaquenil for my mild lupus about 3 weeks ago and I noticed that I am having less appetite these days. I get hungry during dinner time, but all the foods does not taste as good as before. It feels weird! Eating delicious food was one of the joy of my life. The food that I used to love does not taste as good as before. humm. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil increased appetite Plaquenil and increased appetite/weight gain Lupus Forums., Plaquenil Side Effects Common, Severe, Long Term - Chloroquine tinnitus Increased thirst loss of appetite mood changes no pulse or blood pressure numbness or tingling in the hands, feet, or lips unconsciousness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Little appetite with plaquenil?" Lupus Community - Support.. Medications That Cause Weight Gain and What to Do About It. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. I did take Plaquenil on its own a few years back when they thought I had SLE but didn't meet the criteria and I vaguely recall some suppression of appetite. After doing some reading, it turns out people could also lose weight during an active episode so not 100% sure what caused the weight loss. Taking plaquenil doesn't increase my appetite or caused weight gain. Have you stopped smoking recently? People that have quit smoking have the tendency to put on some pounds. It could be a matter of your body adjusting to these changes -- starting a new drug and stopping smoking. Don't beat yourself up over this, you don't need that stress.