To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation. What does plaquenil trat Chloroquine psychosis How good is plaquenil for diabetes Plaquenil changed your hair H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution. Screening Tests The primary screening tests are automated visual fields plus spectral-domain optical coherence tomography SD OCT. These should look beyond the central macula in Asian patients. These should look beyond the central macula in Asian patients. Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center. Plaquenil oct macula Hydroxychloroquine-Induced Retinal Toxicity - American., Plaquenil Toxicity - Retina Image Bank Autophagy flux chloroquine SD Spectral Domain OCT With early Hydrochloroquine retinopathy, SD-OCT can detect outer layer retinal abnormalities Specifically, SD-OCT can detect loss of the perifoveal photoreceptor inner segment/outer segments line PIL At the macula, an ovoid appearance can appear described as “flying saucer” sign by Chen, et al18 ILM IPL OPL Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Recommendations on Screening for Chloroquine and.. Will you have Macular degeneration with Plaquenil - eHealthMe. Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. SD-OCT is capable of detecting characteristic macular changes of HCQ toxicity. These typical macular abnormalities include loss of the parafoveal ellipsoid zone EZ, parafoveal thinning of the outer nuclear layer ONL and inner plexiform layer IPL, the “flying saucer” sign, and peripapillary nerve fiber layer thinning 12 – 14. Optical coherence tomography OCT January 5, 2017 Re "Plaquenil Toxicity Screening" Presentation. To whom it may concern, I would like to extend my apology for not properly submitting the forms for the requested presentation listed above. Moving forward I will be emailing all requests to make the follow up process easierand not mail.