Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Mylan pharmaceuticals hydroxychloroquine Plaquenil red spots on chest and back Plaquenil usage and autism Does plaquenil treat rhupus If you take Plaquenil for your inflammatory disease, your ophthalmologist will check for damage to the retina in the back of the eye while you take the drug. The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience. Yes, it is standard to have an ophthalmologist exam every 6 mths or 1 yr when taking Plaquenil. My rheumy says 1 yr is ok, as problems very seldom develop. I don't know of anyone here who has had any problems. If you do have problems, with the 1 yr exam they will be caught and are reversible by stopping the plaquenil. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil ophthalmologist or optometrist Ophthamologist or Optometrist? -, Despite Plaquenil dosing recommendations, retinal toxicity. Chloroquine injection routePlaquenil standard of care Plaquenil Hydroxychloroquine sulfate is a drug originally used to prevent or treat malaria. Malaria is a serious but rare disease caused by bites from infected mosquitos. Now the drug is used to treat inflammatory diseases. What Is Plaquenil? - American Academy of Ophthalmology. Eye exam / Plaquenil -. Has anyone experienced plaquenil toxicity with damage to eyes?. The risk for Plaquenil toxicity increases after five years, and retinal changes take time to develop. So keep in mind that patients who have been switched to a newer medication could still demonstrate toxicity if they were once on Plaquenil. 1. Marmor MF, Kellner U, Lai TY, et al. American Academy of Ophthalmology. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. The latest screening guidelines were published in 2016 by the American Academy of Ophthalmology Table 1. The most important risk factors are dosage and duration of use. Dosage greater than 5.0mg/kg over five years dramatically increases the risk of retinal toxicity, and high doses can be exceedingly dangerous.