The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Sudden withdrawal of hydroxychloroquine Methotrexate sulfasalazine and hydroxychloroquine Turmeric and plaquenil Plaquenil and taste buds Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Hello thanks for your time. I started both of these ten weeks ago, I'm on 400mg hydroxy and 25mg of methotrexate. Last week I got in such a state about having to take them and it's got to a point where I constantly feel sick because I'm so anxious of having them, so I've been taken off hydroxychloroquine for two weeks so that now I only have medication on a Monday, I thought this would help. Interaction between Methotrexate and Plaquenil There is no known interaction between Methotrexate and Plaquenil in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Plaquenil or methotrexate Does anyone take methotrexate and hydroxychloroquine., Methotrexate and hydroxychloroquine Rheumatoid Arthritis. Chloroquine oral pigmentationChloroquine interfere nucleic acid biosynthesisInstructions for taking chloroquine I had a biopsy and my doctor said he believes it is morphea. I am waiting on my blood test to come back and he said as soon as it does he will put me on both methotrexate and plaquenil. The doctor is. Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma.. Compare Methotrexate vs Plaquenil for Lupus.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Dosage While in some cases, lower doses of NSAIDS are effective, in rheumatoid arthritis and other forms of inflammatory arthritis a higher dose is often required to decrease inflammation. A lower dosage can initially be used if inflammation is mild, if mechanical pain is the major problem. Ok, here is a question that we all could probably use an answer to; Methotrexate or Plaquenil for CREST Scleroderma. I have read Plaquenil is better for Lupus but Methotrexate is better for Scleroderma. Doctor said either is fine, but she wants me to choose. What is your experience with either or both. I need reviews. Oct 09, 2015 I had a biopsy and my doctor said he believes it is morphea. I am waiting on my blood test to come back and he said as soon as it does he will put me on both methotrexate and doctor is a very good derm.