Newer studies have preferred practice protocols be changed to using spectral-domain OCT technology as the main screening device for detection of early retinal changes in plaquenil toxicity. The patient reported that she was in reasonably good health despite a long-term history of lupus. Plaquenil and coughing Plaquenil and pregnancy risk Plaquenil reviews rheumatoid arthritis Symptoms and SignsMechanism of ToxicityMedication DosageRisk For ToxicityMonitoring GuidelinesConclusion Multifocal electroretinography mfERG, spectral domain optical coherence tomography SD-OCT, and fundus autofluorescence FAF add sensitive objective data that can confirm suspicions from a borderline visual field or show anatomic damage before there is any visible “classic” bull's eye retinopathy.2, 3 Recent recommendations from the American Academy of Ophthalmology AAO emphasized the importance of adding objective tests and the rationale for recognizing this toxicity early to. To analyze Humphrey visual field HVF findings in hydroxychloroquine HCQ retinal tests were interpreted retrospectively in this observational case series of 15 patients with HCQ toxicity. Patients seen at Lahey Clinic were identified by. In addition to medication for her lupus, she was also being treated with glyburide for diabetes and an unkown medication for hypertension. She was taking 200 milligrams of plaquenil per day to treat her lupus and had been on this dose level for the past twenty years. Plaquenil maculopathy visual field Multimodal Imaging in Plaquenil Toxicity, Disparity between Visual Fields and Optical Coherence. Is plaquenil a anti-inflammatory Visual fields. The subjective component to HCQ retinopathy screening is an automated visual field testing the central 10° of vision. The earliest signs of HCQ retinopathy on a central visual field may present as a cluster of paracentral points with decreased sensitivity. These points may be only mildly depressed. Hydroxychloroquine retinopathy A review of imaging. Humphrey visual field findings in hydroxychloroquine toxicity. Recommendations on Screening for Chloroquine and.. Nov 01, 2015 SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity. Visual field abnormalities occurred in 35 patients. Five patients developed hydroxychloroquine ocular adverse effects, of which 4 were visual field defects and 1 was significant vortex keratopathy. None of these patients developed visual symptoms, changes in visual acuity, or fundus abnormalities resulting from drug toxic effects nor did they. The Risk of Retinal Toxicity with Plaquenil. Posted. renal or liver failure. Early detection of the maculopathy is of critical importance to discontinue Plaquenil in order to stop or slow retinal damage. evident early structural changes can be subtle and usually preceded by abnormalities in functional tests such as visual field.