Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine salt cambodia resistance Hydroxychloroquine cause weight loss Chloroquine phosphate degradation Vortex whorl keratopathy. The aminoquinoline antimalarial drugs amodiaquine, chloroquine, mepacrine quinacrine, and hydroxychloroquine Plaquenil® are another common cause of drug-induced corneal deposits. Hydroxychloroquine is frequently used in the United States to treat rheumatoid arthritis and lupus erythematosus. Corneal verticillata whorl keratopathy •“ hloroquine, and less frequently HCQ, can cause whorl-like intraepithelial deposits verticillata in the cornea. These corneal changes are not a direct marker for retinal damage, are not associated with visual loss, and in contrast to retinopathy are usually reversible.” Hydroxychloroquine Keratopathy - Example #1. Hydroxychloroquine rarely can be seen as deposits in the basal epithelium of the cornea as shown in this image white arrows. This occurs commonly in patients taking chloroquine, but rarely in patients taking hydroxychloroquine. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Whorl keratopathy plaquenil Does Patient with Lupus Have Plaquenil Retinopathy?, COPE Disclosures Plaquenil Toxicity Update Diopsys for plaquenilPlaquenil order online Cornea verticillata also called vortex keratopathy, whorl keratopathy, or Fleischer vortex describes a whorl-like pattern of golden brown or gray opacities in the cornea. It is termed cornea verticillata from the Latin noun “verticillus,” meaning “whorl”. Cornea Verticillata - EyeWiki. Hydroxychloroquine Keratopathy - Example #1 - The Retina.. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Like a number of other drugs, HCQ and CQ can cause corneal verticillata also known as vortex keratopathy. These epithelial changes arise due to precipitation of the drug, typically forming a whorl-like pattern that is reversible with drug cessation. Chloroquine CQ is used to prevent and treat malaria and amebiasis,1 while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome.2 Both medications can cause corneal deposits, posterior subcapsular lens opacity. The macula. The cornea may become affected relatively commonly by an innocuous vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine.