Chloroquine and early pregnancy

Discussion in 'Chloroquine 250' started by gsmmost, 07-Mar-2020.

  1. Topper XenForo Moderator

    Chloroquine and early pregnancy


    Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. AU TGA pregnancy category D: Drugs which have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects.

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    Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. OBJECTIVE The use of hydroxychloroquine HCQ in pregnancy remains controversial. The recent demonstration that HCQ passes across the placenta, with cord blood concentrations nearly identical to those found in maternal blood, emphasizes the need for careful evaluation of pregnancies in women receiving HCQ. Along with the date of implantation, these factors will influence how early you can get a positive pregnancy test. Deciding when to take a pregnancy test is a risk-benefit calculation testing earlier than 12 DPO means weighing the risk of being disappointed about a possibly false result against the unlikely outcome of an early positive.

    US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Accompanying texts should be consulted for further details.

    Chloroquine and early pregnancy

    Chloroquine MedlinePlus Drug Information, Safety of hydroxychloroquine in pregnant patients with.

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  6. The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in eleven lactating mothers following a single oral dose of chloroquine 600 mg base. The maximum daily dose of the drug that the infant can receive from breastfeeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy.

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    Plaquenil hydroxychloroquine has a good safety record in lupus pregnancy, and is usually continued if needed to control maternal lupus. Management and Monitoring. Lupus pregnancy should be timed to coincide with a period of good disease control if at all possible. Hydroxychloroquine is a medication used to prevent and treat malaria and to treat autoimmune conditions such as rheumatoid arthritis or lupus. Hydroxychloroquine is sold under several brand names, including Plaquenil®. For more information on rheumatoid arthritis or lupus in pregnancy please see. Currently, there are no viable treatment options to prevent the spread of ZIKV. However, in a study by Delvecchio et al. 2016, 17 the potential for the antimalarial agent chloroquine CQ to inhibit the endocytosis of ZIKV within human brain microvascular endothelial and neural stem cells was demonstrated in vitro.

     
  7. LinkerCH Moderator

    Selected from data included with permission and copyrighted by First Databank, Inc. Activation of the RhoA–YAP–β‐catenin Signaling Axis. Repurposing Drugs in Oncology ReDO—chloroquine and. Researches Say Hydroxychloroquine Can Help Treat Cancer.
     
  8. subzey Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine - Wikipedia PLAQUENIL®HYDROXYCHLOROQUINE SULFATE, USP Water for Pharmacuetical Use FDA
     
  9. rokihois Moderator

    Malaria Treatment and Prevention - U. S. Pharmacist Chloroquine Chloroquine phosphate, a synthetic form of quinine, was introduced after World War II and is still the drug of choice for P. falciparum infections that are not chloroquine resistant. Since there are few reported chloroquine-resistant strains of P. malariae, P. vivax, and P. ovale, chloroquine is the drug of choice in these infections.

    Effects of chloroquine on viral infections an old drug.