Hydroxychloroquine retinopathy mechanism

Discussion in 'Chloroquine Drug' started by -John-, 02-Mar-2020.

  1. PrivatePerson New Member

    Hydroxychloroquine retinopathy mechanism


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. Hydroxychloroquine binds strongly to melanin and can deposit in melanin-containing tissues such as the skin and the eyes, which might explain certain tissue-specific mechanisms such as.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Hydroxychloroquine retinopathy mechanism

    Hydroxychloroquine-related retinal toxicity Rheumatology Oxford., Hydroxychloroquine DermNet NZ

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  6. HCQ is widely used for the treatment of rheumatic diseases, particularly lupus and RA. It is generally well tolerated, but retinopathy is a concern. Retinopathy is rare, but is sight threatening, generally irreversible and may progress even after cessation of therapy. Damage may be subclinical.

    • Hydroxychloroquine-related retinal toxicity Rheumatology..
    • Mechanisms of action of hydroxychloroquine and chloroquine..
    • Hydroxychloroquine - Wikipedia.

    The idiosyncratic nature of this adverse effect may be related to interindividual differences in drug metabolism. To understand why only some patients develop retinopathy, better pharmacokinetic models need to be developed, and further elucidation of the precise mechanism of retinal damage is required. Chloroquine and hydroxychloroquine are drugs with still incompletely understood mechanisms of action, but their ability to alter intracellular pH, suppress CD4+ T-cells activity and promote the activation of CD8+ T-cells makes them useful in an array of disorders of different etiologies 1 2. The recommendations on eye screening for hydroxychloroquine or chloroquine retinopathy have been revised by the American Academy of Ophthalmology. 22 It is strongly recommended that all patients beginning hydroxychloroquine or chloroquine therapy have a baseline examination within the first year of starting the drug to document any complicating.

     
  7. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chloroquine phosphate C18H32ClN3O8P2 - PubChem Chloroquine - Drug Monograph - Pharmacokinetics of Chloroquine and Metronidazole in Rats
     
  8. htsystems Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Aralen chloroquine Malaria Drug Side Effects & Dosage CHLOROQUINE PHOSPHATE, USP Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs
     
  9. Volkxxx Moderator

    Safety of the combination of chloroquine and methylene. Therefore, standard dosages of MB appear to be safe in G6PD‐deficient African populations with predominantly class III G6PD deficiency. Introduction Malaria remains the most important parasitic disease and is globally responsible for 300–500 million fever episodes and 1.5–2.7 million deaths per year WHO 1997.

    CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria
     
  10. .BY Guest

    Hydroxychloroquine Uses, Dosage & Side Effects - Hydroxychloroquine dosing information. Usual Adult Dose for Malaria Treatment of the acute attack 800 mg 620 mg base followed in 6 to 8 hours by 400 mg 310 mg base, then 400 mg 310 mg base once a day for 2 consecutive days; alternatively, a single dose of 800 mg 620 mg base has also been effective

    Hydroxychloroquine DermNet NZ