Here we described a non-diabetic patient with RA who developed hypoglycaemia under hydroxychloroquine (HCQ) treatment. We also discussed the possible mechanisms of hypoglycaemia due to HCQ. Plaquenil ophthalmology Chloroquine endocytosis inhibitor Chloroquine phoenix cells PLAQUENIL has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with and without antidiabetic medications. Patients treated with PLAQUENIL should be warned about the risk of hypoglycemia and the associated clinical signs and symptoms. Hypoglycaemia is a rare adverse effect of anti-malarials. Although, some cases in the literature about hypoglycaemia related to chloroquine CQ is reported 1, 2, there is only one RA patient with diabetes mellitus who developed hypoglycaemia due to HCQ 3. Re Plaquenil and hypoglycemia Reply #3 on March 05, 2011, PM I never did take plaquenil when it was offered by the rheumatologist, mainly because I had serious shingles which affected my eyes and I was afraid to take anything that might cause more problems with my eyes at the time. He had a history of pain and swelling in his fingers, wrists, elbows and shoulders for 3 yrs. A 62-yr-old man was admitted to our hospital with symmetric polyarthritis and morning stiffness for more than 2 h in 2005. Plaquenil hypoglycemia Hydroxychloroquine - Wikipedia, Hypoglycaemia induced by hydroxychloroquine in a non. Does plaquenil caus stiff legsWhat is in plaquenilChloroquine and primaquine Antimalarials and effects on glucose metabolism. The antidiabetic effect of chloroquine CQ was first described in 1984 in a patient with severe insulin resistance in whom the addition of CQ dramatically reduced his insulin requirements Blazar et al. 1984. A favorable effect of hydroxychloroquine on glucose and lipid.. Plaquenil and hypoglycemia - Sjogren's World. Plaquenil hydroxychloroquine – New Warnings. Summary Hypoglycemia is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Methotrexate, and have High blood pressure. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food. Sep 13, 2019 Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Yes, plaquenil can cause low blood sugars. Eat frequent meals with carbs and protein but good carbs with fiber like oatmeal or whole wheat toast with peanut butter. I like the lowered blood sugar effect b/c I have type 2 diabetes but before I got type 2, I had some low sugars with plaquenil for sure.