It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Hydroxychloroquine retinopathy Plaquenil and ativan Later in the disease, patients can develop a bilateral bull's eye maculopathy, characterized by a ring of retinal pigment epithelium RPE depigmentation in the macula, sparing the fovea, which is often accompanied by paracentral and central scotomas 5. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. certain eye problems macular. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Plaquenil macula Retinal toxicity associated with chronic exposure to., Plaquenil Oral Uses, Side Effects, Interactions. Chloroquine and omeprazole I am newly "diagnosed", though still waiting for it to be official. Haha! Anyway I was diagnosed with dry macular degeneration 7 years ago. A recent exam showed it has worsened. I have also seen 3 rheumatologists, and 2 of them say I should take Plaquenil and the risk of damage to my macula is not big enough to not take the Plaquenil. One. What about Plaquenil and Macular Degeneration? - Inspire. Hydroxychloroquine-Induced Retinal Toxicity - American.. Plaquenil in Los Angeles, CA Macula and Retina Institute. With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Frequency not reported Maculopathies and macular degeneration may be irreversible, extra-ocular muscle palsies reversible, nystagmus -Blurring of vision is due to a disturbance of accommodation which is dose dependent and reversible.-Retinopathy is uncommon if the recommended daily dose is not exceeded. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful.