Chloroquine methemoglobin

Discussion in 'Hydroxychloroquine Plaquenil' started by AlexanderG, 09-Mar-2020.

  1. gruz-trans Well-Known Member

    Chloroquine methemoglobin


    Methemoglobin results from the presence of iron in the ferric form instead of the usual ferrous form. This results in a decreased availability of oxygen to the tissues.

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    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. PRESCRIBING INFORMATION WITH PATIENT MEDICATION INFORMATION. Pr PRIMAQUINE® primaquine phosphate tablets USP. 26.3 mg primaquine phosphate equivalent to 15 mg primaquine base THERAPEUTIC CLASSIFICATION. Antimalarial. 1 PHARMACOLOGY. Primaquine is an 8aminoquinoline anti- -protozoal agent which is highly active against exo- Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

    As levels rise above 15%, neurologic and cardiac symptoms arise as a consequence of hypoxia. After acute exposure to an oxidizing agent, it is advisable to treat patients with methemoglobin levels of 20% or higher (or lower levels, such as 10%, if there are significant comorbidities especially in the presence of end-organ dysfunction. This structural change causes an alteration in the blood’s ability to bind oxygen. Symptoms are proportional to the methemoglobin level and include skin color changes and blood color changes at levels up to 15% (see the image below).

    Chloroquine methemoglobin

    Chloroquine Oral Uses, Side Effects, Interactions., PRESCRIBING INFORMATION WITH PATIENT MEDICATION INFORMATION

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  5. Methemoglobinemia MetHb is a blood disorder in which an abnormal amount of methemoglobin is produced. Hemoglobin is the protein in red blood cells RBCs that carries and distributes oxygen to the body. Methemoglobin is a form of hemoglobin.

    • Methemoglobinemia MedlinePlus Medical Encyclopedia.
    • Chloroquine - Wikipedia.
    • Studies of Methemoglobin Concentrations of Three Human..

    Any drug that interferes with these mechanisms can lead to methemoglobinemia.1,2 Thus, it is important to take an appropriate drug history particularly for drugs like chloroquine as was observed in our second case.1,2 Acquired methemoglobinemia incidence may be much higher than is documented. Often, this is associated with the use of or. Methemoglobin is not stable in samples of blood and should be measured promptly. Otherwise the measured level may be lower than the values at the time cyanosis was observed. Cyanosis with a gray-brown hue that is unresponsive to oxygen occurs when the fraction of hemoglobin existing as methemoglobin exceeds 15%. Chloroquine overdose is a life-threatening emergency and should be managed with cardio-respiratory and hemodynamic support, monitoring of potassium along with management of arrhythmias and convulsions, as necessary. A patient who survives the acute phase and is asymptomatic should be closely observed until all clinical features of toxicity resolve.

     
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