To date, it was assumed that chloroquine increases the sensitivity of cancer cells to chemotherapy by means of a direct effect on the cancer cells. However, a recent study has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. Aralen ancestral tomb Chloroquine and proguanil Chloroquine dosage lupus The purpose of this study is to test the hypothesis that chloroquine will reduce the ability of ductal carcinoma in situ DCIS to survive and spread. Participants will receive either chloroquine standard dose 500mg/week or chloroquine low dose 250mg/week for 1 month prior to surgical removal of the tumor. Chloroquine CQ is a well known, well tolerated medication that has been used for many years traditionally for arthritis, lupus, and malaria. It has anti-inflammatory properties but is often the drug of choice for arthritis and malaria due to its few side effects. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells. The anti-cancer effect of the antimalarial agent chloroquine when combined with conventional chemotherapy has been well documented in experimental animal models. This blood vessel normalization results in an increased barrier function on the one hand, and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy. Chloroquine and breast cancer Chloroquine plaquil combinations - Ovarian cancer - Inspire, A Phase 2 Randomized, Double-blind Trial Evaluating the. Plaquenil drowsinessPlaquenil somnolence Autophagy is one way of killing cancer cells, which brings the story of chloroquine to the treatment of breast cancer. Many forms of breast cancer begin with pre-cursor cells, anomalous cells among the normal fat and tissue cells of the breast. Anti-malaria Drug Quinine Heads the List of Breast Cancer Clinical Trials. Chloroquine & Hydroxychloroquine supporting chemo.. Roles of autophagy in breast cancer treatment Target, bystander or.. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. found that chloroquine suppressed the growth and metastasis of melanoma by acting on tumor. Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines.