Chloroquine and breast cancer

Discussion in 'Northwest Pharmacy' started by Californiy, 09-Mar-2020.

  1. ray315 Moderator

    Chloroquine and breast cancer


    To date, it was assumed that chloroquine increases the sensitivity of cancer cells to chemotherapy by means of a direct effect on the cancer cells. However, a recent study has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors.

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    The purpose of this study is to test the hypothesis that chloroquine will reduce the ability of ductal carcinoma in situ DCIS to survive and spread. Participants will receive either chloroquine standard dose 500mg/week or chloroquine low dose 250mg/week for 1 month prior to surgical removal of the tumor. Chloroquine CQ is a well known, well tolerated medication that has been used for many years traditionally for arthritis, lupus, and malaria. It has anti-inflammatory properties but is often the drug of choice for arthritis and malaria due to its few side effects. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells.

    The anti-cancer effect of the antimalarial agent chloroquine when combined with conventional chemotherapy has been well documented in experimental animal models. This blood vessel normalization results in an increased barrier function on the one hand, and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

    Chloroquine and breast cancer

    Chloroquine plaquil combinations - Ovarian cancer - Inspire, A Phase 2 Randomized, Double-blind Trial Evaluating the.

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  4. Autophagy is one way of killing cancer cells, which brings the story of chloroquine to the treatment of breast cancer. Many forms of breast cancer begin with pre-cursor cells, anomalous cells among the normal fat and tissue cells of the breast.

    • Anti-malaria Drug Quinine Heads the List of Breast Cancer Clinical Trials.
    • Chloroquine & Hydroxychloroquine supporting chemo..
    • Roles of autophagy in breast cancer treatment Target, bystander or..

    Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. found that chloroquine suppressed the growth and metastasis of melanoma by acting on tumor. Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines.

     
  5. alex-ap Well-Known Member

    In some cases, they may not be available in every strength or form as the brand-name drug. Rapid Heartbeat with Plaquenil - Lupus - MedHelp PLAQUENIL Side Effects, Reviews by Patients - Hydroxychloroquine Sulfate Chest Pain Reports - DrugInformer
     
  6. Torchiva Moderator

    Hi, I was diagnosed with RA and was put on sulfa, my rheumy tried adding mtx but i had awful side effects so am now on hydroxychloroquine and sulfa..this combination worked for anyone? Hi I've been on this combination for a few months and unfortunately it hasn't worked for me - but that's not to say it won't for you, we are all different in how we react to drugs. Sulphasalasine was helpful in my case but took 12 weeks to kick in. Hydroxychloroquine Side Effects, Dosage, Uses, and More Plaquenil vs. Azulfidine Prescription Treatment for. Methotrexate, Plaquenil or Sulfasalazine Azulfidine.
     
  7. Ru-WEB XenForo Moderator

    Plaquenil hydroxychloroquine and eye screening Jitander Dudee Plaquenil hydroxychloroquine and eye screening. In our eye clinic we frequently see patients who need to be screened because they have been prescribed hydroxychloroquine Plaquenil and have concerns, so I wanted to write a short article summarizing the necessity and purpose of proper eye screening in these individuals.

    Plaquenil 200mg Film-coated Tablets - Patient Information Leaflet PIL.
     
  8. duff Moderator

    Antimalarial drug resistance P. falciparum is now highly resistant to chloroquine in most malaria-affected areas. Resistance to SP is also widespread and has developed much more rapidly. Resistance to mefloquine is confined only to those areas where it has been used widely Thailand, Cambodia, and Vietnam but has arisen within six years of systematic deployment.

    CDC - Malaria - Glossary