While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. The studies that do exist show mixed results (some show Nonetheless, despite the lack of clinical studies, rheumatologists feel that hydroxychloroquine may have a potential beneficial effect in helping patients with symptoms of fatigue and achiness, which are common complaints in patients with Sjögren’s. Does hydroxychloroquine cause discoloration of palms of hands Hydroxychloroquine med Non aqueous titration of chloroquine phosphate Mar 09, 2011 They cannot help us if we don't tell them what is wrong! I thought I was beginning to get toxic,and was going to have to stop taking plaquenil. It was only dry eyes! I am aware of the toxicity issues associated with this drug, and dry eyes can be a side effect. However, the med has helped my RA. However rheumy says plaquenil does not target the specific symptoms of dry eyes and dry mouth. She is right. I treat my dry eyes with restasis drops and the dry mouth comes and goes. Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Plaquenil belongs in a class of medications known as disease-modifying antirheumatic drugs DMARDs. The good news is that hydroxychloroquine targets the immune system without causing an increase in the risk of infection or cancer that can be seen with other immunosuppressant medications. How the drug works is unclear, but recent research has pointed to an inhibitory effect on toll-like receptors that are proteins involved with inflammation. Does plaquenil help dry eyes Plaquenil Hydroxychloroquine - Side Effects, Dosage., Study Raises Questions about Sjogren's and Plaquenil Hives on my buttocks and thighs plaquenilHow good is plaquenil for diabetes Sjögren’s syndrome, which causes dry eyes and dry mouth. Plaquenil lowers your immune system’s ability to cause inflammation. This can help control symptoms like rashes, skin and mouth sores and joint pain. Plaquenil and your eyes. A rare side effect of Plaquenil is damage to the eye's retina. What Is Plaquenil? - American Academy of Ophthalmology. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Plaquenil Side Effects on Your Eyes and Vision. In addition to dry eyes and mouth, this can result in difficulty breathing and problems with digestive and bowel function. As with most autoimmune illnesses, it is much more common in women than men. Treatment includes artificial tears and saliva and, in more severe cases, immune blockers such as prednisone, Plaquenil and even the cancer medication Methotrexate. Two drugs approved for dry mouth, pilocarpine Salagen and cevimeline Evoxac, may help dry eyes. While they aren’t approved for dry eyes, your doctor may prescribe them for that purpose. Also, if you take one of these drugs for dry mouth, it may help your eyes. In summary, if you have Sjögren’s, hydroxychloroquine may be an option to help your symptoms. Because there are other more effective therapies available to treat dry eyes and dry mouth, it is typically prescribed to help musculoskeletal pain and fatigue. Be patient, as the drug may take up to 6 months to see a beneficial effect.