My husband has been taking Plaquenil (generic hydroxychloroquine) for almost 2 yrs., under a rheumatologist's care. He became very ill, and was diagnosed w/ viral meningial encephalitis. We were much later told that the Plaquenil had "lowered his tolerance to infection, as it is also an immuno-suppressant." In essence, the medicine allowed the viral infection to cross the barrier between his brain and blood/lungs. Plaquenil retinopathy visual fields Hydroxychloroquine renal toxicity The answer was that while Hydroxychloroquine, the generic name for Plaquenil and the tablet I take in the same dose as yourself i.e. 200mg a day at the moment, is a disease modifying drug and an anti-malarial, it is also a mild immunosuppressant too. So this could be why your immune system is so low at the moment. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. TNF inhibitors are drugs that help stop inflammation. They're used to treat diseases like rheumatoid arthritis RA, juvenile arthritis, psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, ulcerative colitis UC, and Crohn's disease. They're also called TNF blockers, biologic therapies, or anti-TNF drugs. (He was never told of that risk when he was put on the medication.) Added : What I failed to mention (above) is that he almost died in April when this happened. His/our question is as to whether he can or should EVER go back on the medication and risk exposure to further illnesses if it is true that Plaquenil or the generic for is, in fact, an immuno-suppressant and presents a serious health risk for him? Plaquenil immunosuppressive therapy Plaquenil Hydroxychloroquine - Side Effects, Dosage., Hydroxychloroquine Side Effects, Dosage, Uses, and More Chloroquine-primaquine-phosphate tabletsPlaquenil eye exam formAvloclor 250mg chloroquine phosphateHyperpigmentation plaquenil Cyclophosphamide Cytoxan® is a potent immunosuppressive agent that is reserved for severe cases of refractory rheumatoid arthritis and those with manifestations such as vasculitis. It is used in the treatment of other autoimmune conditions including lupus and vasculitis. Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center. TNF Inhibitor Drugs Autoimmune Disease Treatments. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. From a technical point of view plaquenil is an immunosuppressant, however, from a medical point of view it is definitely NOT considered as one as its action is so light as to be insignificant in that respect. Published evidence says that it is mediated by T-lymphocytes. Plaquenil is an anti-inflammatory drug approved by the FDA for malaria, lupus erythematosus, and rheumatoid arthritis. It has an effect on T-lymphocyte mediated inflammation, making it a logical choice for a treatment trail for alopecia areata. Immunosuppressive drugs, including cyclophosphamide and azathioprine, and adrenal hormones, such as prednisone PDS, are clinical drugs used in the treatment of LN 2,3. However, these drugs present significant side effects with long-term and high-dose application.