It's been found that zoloft prevents the movement of serotonin into nerve endings. Antidepressants such as Zoloft stop the abnormal function of serotonin We all know that the prevention of migraines can be had if we find out the cause of the migraine. So in order to have migraine relief, a migraine sufferer has two choices. One is to try to find out what is triggering them, or go to a headache specialist if that doesn't work. Headache specialist have their own course of treatments. Most prescribe several different preventive medicines. Most likely one of those medicines will be an antidepressant. Let's say for instance a person has sinus migraines/headaches. It's worked for years for migraine treatment and has took the edge off migraines for many. Then the sinuses will have to be treated before the headache can be relief. 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There is so much ado about Viagra that I consider it my duty to express my humble opinion as well. Zoloft (sertraline) is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Zoloft may also be used for purposes not listed in this medication guide. You should not use Zoloft if you also take pimozide, or if you are being treated with methylene blue injection. Do not use Zoloft if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. 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