To assess the relationship between low-dose tamoxifen, usage and endometrial cancer in breast cancer patients. In this case-control study, the records of the 1017 patients treated at Wilford Hall Medical Center for primary breast cancer between 19 were reviewed. Dose and duration of tamoxifen therapy were recorded as well as the presence of a uterus. Potential confounding variables including diabetes mellitus, hypertension, age, weight, tobacco use, and family history of breast or gynecologic cancer were recorded. Of the 1017 patients in the study, 56 had inadequate records and 375 had undergone a prior hysterectomy and these patients were excluded from the study, leaving 586 eligible patients. Of these 586 women with primary breast cancer and no previous hysterectomy, 108 patients had received tamoxifen, 10 mg twice a day for greater than 1 year. Four of the 108 patients subsequently developed endometrial adenocarcinoma. Four hundred seventy-eight breast cancer patients did not receive tamoxifen and 4 later developed endometrial adenocarcinoma. The odds ratio for the development of endometrial cancer when exposed to tamoxifen was 15.2 with a 95% confidence interval of 2.8–84.4. buy zovirax topical ointment Had mastectomy on my left breast, 6 chemo and 15 radiotherapy! Last month I had a ultrasound and I have hyperplasia on the endometrio! Consultants didn't want to do anything unless I'm bleeding wich make me feel so stressed! I know that this is a side effect of the tamoxifen but I'm scared knowing that I'm on tamoxifen for 3 more years and my endometrio could continue growing! Can anyone tell me if this happen to you and if you got hysterectomy? Propecia results before and after Buy super kamagra online uk Buy cialis uk suppliers I am going to begin tamoxifen soon and wondered if any of you talked to your onc about having a hysterectomy? It is so easy these days, done. xanax jewelry Tamoxifen is a mixed estrogen agonist/antagonist that has a proliferative effect on the. lead to an increase in D&C and hysterectomy rates. Are you asking if Tamoxifen gave anyone here uterine cancer? If you are- Yes I was on Tamoxifen a relatively short time months short of a. Dear Onco Link "Ask The Experts,"One year ago, I was diagnosed with DCIS. The tumor was excised successfully with free margins but the words "microinvasive" were used. To be on the safe side, my surgeon performed an axillary node dissection and all nodes were negative. I received 25 radiation treatments and was prescribed Tamoxifen. The Tamoxifen caused severe bleeding to the point that I recently underwent a total hysterectomy. My question: I'm confused about the fact that since I no longer have ovaries to produce estrogen, how does the Tamoxifen help me? Thank you for this Internet site; it has been the most informative site. Kevin Fox, MD, Assistant Director, Clinical Affairs and Associate Professor of Hematology/Oncology at the Abramson Cancer Center of the University of Pennsylvania, responds: Tamoxifen doesn't "need" ovaries present producing estrogen to be valuable. SNJulie wrote: Many times in this journey, I have regretted not having a bi-lateral instead of the lumpectomy... I am not a bit afraid of a surgery..rather have that than more treatments. I am going to begin tamoxifen soon and wondered if any of you talked to your onc about having a hysterectomy? It is so easy these days, done with laproscopy, and I wonder why they dont do it to eliminate the risks of endo and uterine cancer. I am so glad to be finished with rads but now start worrying about the SE of tamoxifen...this ever end?????????? Julie Log in to post a reply Jul 23, 2007 PM burns_la wrote: I had invasive DCIS, mast, immed tram, chemo..on to Tamoxifen. I am a DES daughter and have a higher risk for a uterine cancer. I asked my Gyn if I could get a hysterectomy to reduce the chance of another cancer to deal with. " He also said that most insurance companies approve surgeries based on what they cover more than what they think you need (even some HMOs! He sent in a request for the surgery, it was approved, I had it done laparascopically (sp? Tamoxifen and hysterectomy A Retrospective Study of Tamoxifen and Endometrial Cancer in., Benign and Hyperplastic Endometrial Changes Associated With. Tamoxifen therapy for breast cancer Abstract. Tamoxifen improves outcome in women with breast cancer and reduces the incidence of estrogen receptor-positive ER+ breast tumors in prevention. Italian Randomized Trial Among Women With Hysterectomy. Has anyone had hysterectomy and ovaries removed because of. Prolonged Tamoxifen Surpasses Oophorectomy in Breast Cancer Following hysterectomy than following hysteroscopy in postmenopausal breast cancer patients with tamoxifen treatment. To the best of our knowledge, this is the. prednisone chest pain If I have a total hysterectomy will I have to continue on Tamoxifen ? posted 8. Then 7 weeks of radiation and I'm scheduled for a hysterectomy on 2/26. Anyway. I would not take tamoxifen unless I had a hysterectomy. some studies have also shown an increase in ovarian cancer. I havae no family history.